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State Street vs. First Trust: Is a Broad Healthcare or Biotech Focus Better for Your Portfolio?

FBT delivered 48.5% returns over one year but carries a 0.55% expense ratio and experiences greater volatility. XLV offers lower costs, with an 0.08% expense ratio, as well as broader diversification across 60 healthcare stocks.

State Street vs. First Trust: Is a Broad Healthcare or Biotech Focus Better for Your Portfolio?

Published July 29, 2026 · Category: Finance

Overview

Determining whether State Street Health Care Select Sector SPDR ETF (NYSEMKT:XLV) or First Trust NYSE Arca Biotechnology Index Fund (NYSEMKT:FBT) fits a portfolio depends on an investor's preference for broad-sector stability or concentrated biotechnology exposure.

Both funds target the healthcare space but with very different scopes. XLV tracks the entire healthcare sector within the S&P 500, including giants in pharmaceuticals and medical devices. FBT focuses strictly on biotechnology companies, offering a narrower and historically more volatile path into medical innovation.

Beta measures price volatility relative to the S&P 500; beta is calculated from monthly returns over the available fund history (up to five years). The 1-yr return represents total return over the trailing 12 months. Dividend yield is the trailing-12-month distribution yield.

Details

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Source

Originally published at www.fool.com.

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Disclaimer: This article is for informational purposes only and does not constitute investment advice. Data may be delayed up to 15 minutes. Past performance is not indicative of future results. Consult a licensed financial advisor before making investment decisions.